According to police in Mai Chau District, the accident occurred at 12.20am when a bus running from Hanoi to Dien Bien hit a truck carrying metal scraps on National Road 6.
The collision left three people including the bus driver dead while 31 other passengers injured, police said, adding that most of the victims have not been indentified yet.
Both the bus and the truck were heavily damaged.
Police are further investigating the cause of the accidents.
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